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Knuckles Nuclear He is the only criminal to have appeared in two episodes of The Jetsons--"The New Car" and "Jane's Driving Lesson". In "The New Car", Knuckles was accompanied by a moll who looked like a doppleganger of Betty Rubble from The Flintstones and also carried a baby gas gun as a weapon. In Knuckles' second appearance, it is implied that he broke out of prison to rob a local bank in Orbit City and is seen wearing attire different from his first episode.
Seen in the original series finale, "Elroy's Mob", Mugsy Megaton was a mobster who employed a freeze gas gun as his weapon (as opposed to Knuckles Nuclear's baby gas gun). Mugsy was accompanied by a not-very-bright accomplice, Microbe, and their unusually wacky gorilla sidekick, Chuckles.
Seen in an episode of the revived Jetsons series, "Astro's Big Moment", Mangler Mars is the mobster who steals a dog named Starbite and enters it in the dog show, threatening George with death if Starbite doesn't win. Mangler's catchphrase to his henchpeople is "Shut up while I'm ___________ ."
Head of the enemy spy organization SNEAK, Skata-Hara mistakes George for being the legendary spy hero Space Bong; she, like Catwoman from the Batman universe, is a temptress who will use sexuality to accomplish her evil deeds.
A tyrannical leader of the circus who uses his band of fleas as his slaves.
A thief who comes into the Jetsons' home pretending to be a child, only to deprive them of their material possessions.
Appearing in the episode "High Moon", Bad Bart Blaster is a rogue space cowboy who makes life miserable for everyone living on an Old West-style planet.
Appearing in "SuperGeorge" (the supposed pilot for Super Jetsons), the Jupiter Juggernaut is a gigantic green-and-purple alien with an angry temper who is SuperGeorge's opponent in the wrestling ring.
A take on "The Godfather"; seen in the episode "Crime Games". The last known villain to appear in The Jetsons.